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Journal article

When half a glass of STAT3 is just not enough.

Abstract:
In this issue of Blood, Bocchini et al report a novel mechanism by which STAT3 mutations result in an unstable protein and give rise to a reduction in STAT3 signalling, suggesting that pathogenic mutations do not always confer dominant negative effects via forming of non-functional STAT3 dimers but some may limit availability of total protein causing STAT3 haploinsufficiency
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1182/blood-2016-11-750539

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Publisher:
American Society of Hematology
Journal:
Blood More from this journal
Volume:
128
Issue:
26
Pages:
3020-3021
Publication date:
2016-12-01
Acceptance date:
2016-12-01
DOI:
ISSN:
1528-0020
Language:
English
Keywords:
Pubs id:
pubs:668086
UUID:
uuid:f79a556a-8686-4379-850f-e55cd290d973
Local pid:
pubs:668086
Source identifiers:
668086
Deposit date:
2017-01-17

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