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Catalytic enantio- and diastereoselective mannich addition of TosMIC to ketimines

Abstract:

Chiral amines bearing a stereocenter in the α position are ubiquitous compounds with many applications in the pharmaceutical and agrochemical sectors, as well as in catalysis. Catalytic asymmetric Mannich additions represent a valuable method to access such compounds in enantioenriched form. Herein, we report the first enantio- and diastereoselective addition of commercially available p-toluenesulfonylmethyl isocyanide (TosMIC) to ketimines, affording 2-imidazolines bearing two contiguous ste...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/chem.201804099

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More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Oxford college:
Wadham College
Role:
Author
More from this funder
Name:
Seventh Framework Programme
Funding agency for:
Franchino, A
Grant:
316955
More from this funder
Name:
University of Colorado Boulder
Publisher:
Wiley
Journal:
Chemistry More from this journal
Volume:
24
Issue:
67
Pages:
17660-17664
Publication date:
2018-09-23
Acceptance date:
2018-09-17
DOI:
EISSN:
1521-3765
ISSN:
0947-6539
Pmid:
30246415
Language:
English
Keywords:
Pubs id:
pubs:923811
UUID:
uuid:f7993151-0c25-460d-ad63-799d3f7a5435
Local pid:
pubs:923811
Source identifiers:
923811
Deposit date:
2018-10-08

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