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Journal article

A synthetic polyphosphoinositide headgroup surrogate in complex with SHIP2 provides a rationale for drug discovery

Abstract:

Phosphoinositides regulate many cellular processes, and cellular levels are controlled by kinases and phosphatases. SHIP2 (SH2 (Src homology 2)-domain-containing inositol-phosphatase-2) plays a critical role in phosphoinositide signaling, cleaving the 5-phosphate from phosphatidylinositol 3,4,5-trisphosphate. SHIP2 is thought to be involved in type-2 diabetes and obesity, conditions that could therefore be open to pharmacological modulation of the enzyme. However, rational design of SHIP2 inh...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1021/cb200494d

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Publisher:
American Chemical Society Publisher's website
Journal:
ACS Chemical Biology
Volume:
7
Issue:
5
Pages:
822–828
Publication date:
2012-02-13
Acceptance date:
2012-02-13
DOI:
ISSN:
1554-8937 and 1554-8929
Pubs id:
pubs:640301
URN:
uri:f7980eff-2fce-4b80-80a2-f7f58237dd6a
UUID:
f7980eff-2fce-4b80-80a2-f7f58237dd6a
Local pid:
pubs:640301
Paper number:
5

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