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60 years of placebo-controlled antipsychotic drug trials in acute schizophrenia: Meta-regression of predictors of placebo response

Abstract:
Objective: A recent meta-regression had shown that the degree of placebo response, which has increased over the decades, is the major predictor of drug-placebo differences in antipsychotic drug trials in acutely ill patients with schizophrenia. Drug response, however, had remained stable. In the current meta-regression we explored the factors that are associated with placebo-response. Method: We searched multiple electronic databases, ClinicalTrials.gov and t... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.schres.2018.05.009

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Publisher:
Elsevier
Journal:
Schizophrenia Research More from this journal
Volume:
201
Pages:
315-323
Publication date:
2018-05-24
Acceptance date:
2018-05-11
DOI:
ISSN:
0920-9964
Keywords:
Pubs id:
pubs:847691
UUID:
uuid:f77b1b59-d8df-4955-b863-e0e6ca19e85a
Local pid:
pubs:847691
Source identifiers:
847691
Deposit date:
2018-05-14

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