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DarTG is a novel toxin-antitoxin system that catalyses the reversible ADP-ribosylation of DNA

Abstract:

The discovery and study of toxin-antitoxin (TA) systems helps us advance our understanding of the strategies prokaryotes employ to regulate cellular processes related to the general stress response, such as defense against phages, growth control, biofilm formation, persistence and programmed cell death. Here we identify and characterise a TA system found in various bacteria, including the global pathogen Mycobacterium tuberculosis and the thermophilic Thermus aquaticus (Taq). The toxin of the...

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Publication status:
Published
Peer review status:
Peer reviewed (other)

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Publisher copy:
10.6084/m9.figshare.4801957.v1

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Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Publisher:
The Microbiology Society Publisher's website
Publication date:
2017-04-04
DOI:
Pubs id:
pubs:687601
URN:
uri:f77527c4-e126-4c7e-b5c5-dff7f4d1bc5c
UUID:
uuid:f77527c4-e126-4c7e-b5c5-dff7f4d1bc5c
Local pid:
pubs:687601

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