Journal article icon

Journal article

N‐glycoproteins exhibit a positive expression level–evolutionary rate correlation

Abstract:

The different proteins of any proteome evolve at enormously different rates. One of the primary factors influencing rates of protein evolution is expression level, with highly expressed proteins tending to evolve at slow rates. This phenomenon, known as the expression level–evolutionary rate (E–R) anticorrelation, has been attributed to the abundance‐dependent deleterious effects of misfolding or misinteraction. We have recently shown that secreted proteins either lack an E–R anticorrelation ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1111/jeb.13420

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
Publisher:
Wiley
Journal:
Journal of Evolutionary Biology More from this journal
Volume:
32
Issue:
4
Pages:
390-394
Publication date:
2019-03-05
Acceptance date:
2019-01-25
DOI:
EISSN:
1420-9101
ISSN:
1010-061X
Pmid:
30697857
Language:
English
Keywords:
Pubs id:
pubs:968782
UUID:
uuid:f74eb230-7f3c-4a73-957a-df62d4cc3d24
Local pid:
pubs:968782
Source identifiers:
968782
Deposit date:
2019-02-05

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP