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Panton-Valentine leucocidin is the key determinant of Staphylococcus aureus pyomyositis in a bacterial GWAS

Abstract:

Pyomyositis is a severe bacterial infection of skeletal muscle, commonly affecting children in tropical regions, predominantly caused by Staphylococcus aureus. To understand the contribution of bacterial genomic factors to pyomyositis, we conducted a genome-wide association study of S. aureus cultured from 101 children with pyomyositis and 417 children with asymptomatic nasal carriage attending the Angkor Hospital for Children, Cambodia. We found a strong relationship between bacteria...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.7554/elife.42486

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
Oxford college:
Wolfson College
ORCID:
0000-0001-6071-6770
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
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Publisher:
eLife Sciences Publisher's website
Journal:
Genetics and Genomics, Microbiology and Infectious Diseases Journal website
Volume:
8
Publication date:
2019-02-22
Acceptance date:
2019-02-21
DOI:
ISSN:
2050-084X
Pubs id:
pubs:975851
URN:
uri:f733ecf5-f65f-4efc-99e0-28800c98f867
UUID:
uuid:f733ecf5-f65f-4efc-99e0-28800c98f867
Local pid:
pubs:975851
Language:
English

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