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Panton-Valentine leucocidin is the key determinant of Staphylococcus aureus pyomyositis in a bacterial GWAS

Abstract:

Pyomyositis is a severe bacterial infection of skeletal muscle, commonly affecting children in tropical regions, predominantly caused by Staphylococcus aureus. To understand the contribution of bacterial genomic factors to pyomyositis, we conducted a genome-wide association study of S. aureus cultured from 101 children with pyomyositis and 417 children with asymptomatic nasal carriage attending the Angkor Hospital for Children, Cambodia. We found a strong relationship between bacteria...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/elife.42486

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Oxford college:
Wolfson College
Role:
Author
ORCID:
0000-0001-6071-6770
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Name:
Wellcome Trust
Grant:
101611/Z/13/Z
Publisher:
eLife Sciences
Journal:
Genetics and Genomics, Microbiology and Infectious Diseases More from this journal
Volume:
8
Article number:
e42486
Publication date:
2019-02-22
Acceptance date:
2019-02-21
DOI:
ISSN:
2050-084X
Language:
English
Pubs id:
pubs:975851
UUID:
uuid:f733ecf5-f65f-4efc-99e0-28800c98f867
Local pid:
pubs:975851
Source identifiers:
975851
Deposit date:
2019-02-22

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