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Journal article

Reproduction, infection and killer-cell immunoglobulin-like receptor haplotype evolution

Abstract:

Killer-cell immunoglobulin-like receptors (KIRs) are encoded by one of the most polymorphic families in the human genome. KIRs are expressed on natural killer (NK) cells, which have dual roles: (1) in fighting infection and (2) in reproduction, regulating hemochorial placentation. Uniquely among primates, human KIR genes are arranged into two haplotypic combinations: KIR A and KIR B. It has been proposed that KIR A is specialized to fight infection, whilst KIR B evolved to help ensure success...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1007/s00251-016-0935-9

Authors


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Department:
Oxford, MPLS, Zoology
Moffett, A More by this author
Chazara, O More by this author
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Department:
Oxford, MPLS, Zoology
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Grant:
DIVERSITY advanced investigator
Publisher:
Springer Berlin Heidelberg Publisher's website
Journal:
Immunogenetics Journal website
Volume:
68
Pages:
755–764
Publication date:
2016-08-12
Acceptance date:
2016-06-24
DOI:
EISSN:
1432-1211
ISSN:
0093-7711
Pubs id:
pubs:634664
URN:
uri:f70d8c78-df6f-4a2d-9e9f-2af06feeb6b5
UUID:
uuid:f70d8c78-df6f-4a2d-9e9f-2af06feeb6b5
Local pid:
pubs:634664

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