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Improved characterisation of MRSA transmission using within-host bacterial sequence diversity.

Abstract:

Methicillin-resistant Staphylococcus aureus (MRSA) transmission in the hospital setting has been a frequent subject of investigation using bacterial genomes, but previous approaches have not yet fully utilised the extra deductive power provided when multiple pathogen samples are acquired from each host. Here, we use a large dataset of MRSA sequences from multiply-sampled patients to reconstruct colonisation of individuals in a high-transmission setting in a hospital in Thailand. We reconstruc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/elife.46402

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
BDI-NDM
Role:
Author
ORCID:
0000-0002-2671-3864
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Role:
Author
ORCID:
0000-0002-4958-2166
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Name:
European Research Council
Grant:
PBDR-339251
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Name:
Chief Scientist Office
Grant:
SIRN10
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Name:
Medical Research Council
Grant:
G1000803
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Name:
Wellcome Trust
Grant:
106698/Z/14/Z
Publisher:
eLife Sciences Publications
Journal:
eLife More from this journal
Volume:
8
Article number:
e46402
Publication date:
2019-10-08
Acceptance date:
2019-10-01
DOI:
EISSN:
2050-084X
Pmid:
31591959
Language:
English
Keywords:
Pubs id:
pubs:1061536
UUID:
uuid:f6f16bbf-6552-4fc5-8248-ac464c9e43cc
Local pid:
pubs:1061536
Source identifiers:
1061536
Deposit date:
2020-01-14

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