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Improved characterisation of MRSA transmission using within-host bacterial sequence diversity.

Abstract:

Methicillin-resistant Staphylococcus aureus (MRSA) transmission in the hospital setting has been a frequent subject of investigation using bacterial genomes, but previous approaches have not yet fully utilised the extra deductive power provided when multiple pathogen samples are acquired from each host. Here, we use a large dataset of MRSA sequences from multiply-sampled patients to reconstruct colonisation of individuals in a high-transmission setting in a hospital in Thailand. We reconstruc...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.7554/elife.46402

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
BDI-NDM
Role:
Author
ORCID:
0000-0002-2671-3864
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Role:
Author
ORCID:
0000-0002-4958-2166
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Grant:
098051
106698/Z/14/Z
Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
8
Pages:
Article: e46402
Publication date:
2019-10-08
Acceptance date:
2019-10-01
DOI:
EISSN:
2050-084X
Pubs id:
pubs:1061536
URN:
uri:f6f16bbf-6552-4fc5-8248-ac464c9e43cc
UUID:
uuid:f6f16bbf-6552-4fc5-8248-ac464c9e43cc
Local pid:
pubs:1061536
Language:
English
Keywords:

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