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Modeling of dynamic cerebrovascular reactivity to spontaneous and externally induced CO2 fluctuations in the human brain using BOLD-fMRI

Abstract:

In this work, we investigate the regional characteristics of the dynamic interactions between arterial CO2 and BOLD (dynamic cerebrovascular reactivity - dCVR) during normal breathing and hypercapnic, externally induced step CO2 challenges. To obtain dCVR curves at each voxel, we use a custom set of basis functions based on the Laguerre and gamma basis sets. This allows us to obtain robust dCVR estimates both in larger regions of interest (ROIs), as well as in individual voxels. We also imple...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.neuroimage.2018.10.084

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More from this funder
Name:
Fonds Recherche Nature et Technologies Quebec
Funding agency for:
Mitsis, GD
More from this funder
Name:
Natural Sciences and Engineering Research Council of Canada
Funding agency for:
Mitsis, GD
More from this funder
Name:
National Institute for Health Research
Funding agency for:
Pattinson, KTS
Publisher:
Elsevier
Journal:
NeuroImage More from this journal
Volume:
186
Pages:
533-548
Publication date:
2018-11-10
Acceptance date:
2018-10-31
DOI:
EISSN:
1095-9572
ISSN:
1053-8119
Keywords:
Pubs id:
pubs:938563
UUID:
uuid:f6e70e7c-79dd-47df-b09c-366686111bf8
Local pid:
pubs:938563
Source identifiers:
938563
Deposit date:
2018-11-07

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