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Thesis

Investigating mechanisms of Epstein-Barr virus reactivation in epithelial cells

Abstract:

Approximately 10% of all gastric cancer cases worldwide are associated with Epstein-Barr virus (EBV) infection. This subgroup differs from non-infected equivalents through a distinct mutational and epigenetic signature, which is crucial for the establishment and maintenance of the viral latent state. Disruption of the latent state and subsequent induction of the lytic cycle, called reactivation, can be used as a therapeutic strategy for this cancer type through either combination with anti...

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Department:
Ludwig Cancer Research Institute
Role:
Author

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Department:
Ludwig Cancer Research Institute
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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