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Quantification of dengue virus specific T cell responses and correlation with viral load and clinical disease severity in acute dengue infection

Abstract:
Background In order to understand the role of dengue virus (DENV) specific T cell responses that associate with protection, we studied their frequency and phenotype in relation to clinical disease severity and resolution of viraemia in a large cohort of patients with varying severity of acute dengue infection. Methodology/Principal findings Using ex vivo IFNγ ELISpot assays we determined the frequency of dengue viral peptide (DENV)-NS3, NS1 and NS5 responsiv... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pntd.0006540

Authors


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Role:
Author
ORCID:
0000-0002-5613-5807
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Name:
National Science Foundation, Sri Lanka
Grant:
NSF/RG/2016/HS/05
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Name:
NIHR Oxford Biomedical Research Centre
Funding agency for:
Ogg, GS
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Name:
Centre for Dengue Research, University of Sri Jayewardenapura
Publisher:
Public Library of Science
Journal:
PLoS Neglected Tropical Diseases More from this journal
Volume:
12
Issue:
10
Article number:
e0006540
Publication date:
2018-10-01
Acceptance date:
2018-08-20
DOI:
EISSN:
1935-2735
ISSN:
1935-2727
Pmid:
30273352
Language:
English
Pubs id:
pubs:923202
UUID:
uuid:f6a2d52e-8a54-4b02-b0cb-3ab97a2b24d2
Local pid:
pubs:923202
Source identifiers:
923202
Deposit date:
2018-10-18

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