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Evidence that the 5p12 variant rs10941679 confers susceptibility to estrogen receptor-positive breast cancer through FGF10 and MRPS30 regulation.

Abstract:

Genome-wide association studies (GWASs) have revealed increased breast cancer risk associated with multiple genetic variants at 5p12. Here, we report the fine mapping of this locus using data from 104,660 subjects from 50 case-control studies in the Breast Cancer Association Consortium (BCAC). With data for 3,365 genotyped and imputed SNPs across a 1 Mb region (positions 44,394,495–45,364,167; NCBI build 37), we found evidence for at least three independent signals: the strongest signal, cons...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


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Name:
Norwegian Regional Health authorities
Grant:
2014061
More from this funder
Name:
National Health and Medical Research Council of Australia
Grant:
1058415
More from this funder
Name:
Department of Defence
Grant:
W81XWH-10-1-0341
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Name:
Post-Cancer GWAS initiative
Grant:
1U19 CA148112
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Name:
National Institutes of Health
Grant:
CA128978
Publisher:
Elsevier
Journal:
American Journal of Human Genetics More from this journal
Volume:
99
Issue:
4
Pages:
903–911
Publication date:
2016-09-15
Acceptance date:
2016-07-16
DOI:
ISSN:
1537-6605 and 0002-9297
Pmid:
27640304
Language:
English
Keywords:
Pubs id:
pubs:645814
UUID:
uuid:f68cc129-305d-415a-b84d-d2c54d86c77d
Local pid:
pubs:645814
Deposit date:
2016-10-05

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