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Plasmodium-infected erythrocytes induce secretion of IGFBP7 to form type II rosettes and escape phagocytosis

Abstract:

In malaria, rosetting is described as a phenomenon where an infected erythrocyte (IRBC) is attached to uninfected erythrocytes (URBC). In some studies, rosetting has been associated with malaria pathogenesis. Here, we have identified a new type of rosetting. Using a step-by-step approach, we identified IGFBP7, a protein secreted by monocytes in response to parasite stimulation, as a rosette-stimulator for Plasmodium falciparum- and P. vivax-IRBC. IGFBP7-mediated rosette-stimulation was rapid ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0002-7324-5792
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Role:
Author
ORCID:
0000-0003-2333-4348
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Name:
Open Fund-Young Individual Research Grant, National Medical Research Council, Ministry of Health, Singapore
Publisher:
eLife Sciences Publications
Journal:
eLife More from this journal
Volume:
9
Article number:
e51546
Publication date:
2020-02-18
Acceptance date:
2020-01-27
DOI:
EISSN:
2050-084X
Pmid:
32066522
Language:
English
Keywords:
Pubs id:
1088346
Local pid:
pubs:1088346
Deposit date:
2020-07-07

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