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Identification of survivin as a promising target for the immunotherapy of adult B-cell acute lymphoblastic leukaemia

Abstract:

B-cell acute lymphoblastic leukemia (B-ALL) is a rare heterogeneous disease characterized by a block in lymphoid differentiation and a rapid clonal expansion of immature, non-functioning B cells. Adult B-ALL patients have a poor prognosis with less than 50% chance of survival after five years and a high relapse rate after allogeneic haematopoietic stem cell transplantation. Novel treatment approaches are required to improve the outcome for patients and the identification of B-ALL specific ant...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.18632/oncotarget.23380

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Funding agency for:
Banham, A
Grant:
Programme grant (13047
Publisher:
Impact Journals Publisher's website
Journal:
Oncotarget Journal website
Volume:
9
Issue:
3
Pages:
3853-3866
Publication date:
2017-12-17
Acceptance date:
2017-11-26
DOI:
ISSN:
1949-2553
Source identifiers:
817391
Keywords:
Pubs id:
pubs:817391
UUID:
uuid:f64acce5-9b37-4591-997a-d90de23b0967
Local pid:
pubs:817391
Deposit date:
2018-01-10

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