- Abstract:
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To identify new regulators of homologous recombination repair, we carried out a genome-wide short-interfering RNA screen combined with ionizing irradiation using RAD51 foci formation as readout. All candidates were confirmed by independent short-interfering RNAs and validated in secondary assays like recombination repair activity and RPA foci formation. Network analysis of the top modifiers identified gene clusters involved in recombination repair as well as components of the ribosome, the pr...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 4.2MB)
-
- Publisher copy:
- 10.1038/celldisc.2015.34
-
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- Publisher:
- Nature Publishing Group: Open Access Journals - Option C Publisher's website
- Journal:
- Cell Discovery Journal website
- Volume:
- 1
- Publication date:
- 2015-12-01
- Acceptance date:
- 2015-09-16
- DOI:
- ISSN:
-
2056-5968
- URN:
-
uuid:f635a405-7da6-469c-8e6e-ce6cba8372e2
- Source identifiers:
-
619156
- Local pid:
- pubs:619156
- Keywords:
- Copyright holder:
- Patrick Herr et al.
- Copyright date:
- 2015
- Notes:
- This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Journal article
A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair
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