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A perturbation in glutathione biosynthesis disrupts endoplasmic reticulum morphology and secretory membrane traffic in Arabidopsis thaliana

Abstract:

To identify potentially novel and essential components of plant membrane trafficking mechanisms we performed a GFP-based forward genetic screen for seedling-lethal biosynthetic membrane trafficking mutants in Arabidopsis thaliana. Amongst these mutants, four recessive alleles of GSH2, which encodes glutathione synthase (GSH2), were recovered. Each allele was characterized by loss of the typical polygonal endoplasmic reticulum (ER) network and the accumulation of swollen ER-derived bodies whic...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Department:
Oxford, MPLS, Plant Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Plant Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Plant Sciences
Role:
Author
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Publisher:
Wiley Publisher's website
Journal:
Plant Journal Journal website
Volume:
71
Issue:
6
Pages:
881-894
Publication date:
2012-07-12
Acceptance date:
2012-03-22
DOI:
EISSN:
1365-313X
ISSN:
0960-7412
URN:
uuid:f62c5dc8-8c1f-4daa-8f8a-49c70fef21d0
Source identifiers:
352733
Local pid:
pubs:352733

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