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Thesis

Investigation of X-ray induced radiation damage in proteins, nucleic acids and their complexes

Abstract:

Macromolecular X-ray crystallography (MX) is currently the dominant technique for the structural eluci- dation of macromolecules at near atomic resolution. However, the progression and deleterious effects of radiation damage remains a major limiting factor in the success of diffraction data collection and subsequent structural solution at modern third generation synchrotron facilities. For experiments conducted at 100 K, protein specific damage to particular amino acids has been widely rep...

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Department:
Linacre
Role:
Author

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Department:
Elspeth Garman
Role:
Supervisor
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Grant:
EP/G03706X/1
Funding agency for:
Project
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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