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2ʹ-Deoxyadenosine 5ʹ-diphosphoribose is an endogenous TRPM2 superagonist

Abstract:

Transient receptor potential melastatin 2 (TRPM2), is a ligand-gated Ca2+-permeable non19 selective cation channel. While physiological stimuli, e.g. chemotactic agents, evoke controlled Ca2+ signals via TRPM2, pathophysiological signals, such as reactive oxygen species or genotoxic stress result in prolonged TRPM2-mediated Ca2+ entry and consequently apoptosis. To date, adenosine 5ʹ-diphosphoribose (ADPR, 1) has been assumed to be the main agonist for TRPM2. Here, we show that 2ʹ-deoxy-ADPR ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/nchembio.2415

Authors


Fliegert, R More by this author
Wolf Pérez, A-M More by this author
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Department:
Oxford, MSD, Pharmacology
Rozewitz, MD More by this author
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Funding agency for:
Potter, B
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Funding agency for:
Guse, AH
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Chemical Biology Journal website
Volume:
13
Pages:
1036-1044
Publication date:
2017-06-26
Acceptance date:
2017-04-27
DOI:
EISSN:
1552-4469
ISSN:
1552-4450
Pubs id:
pubs:691584
URN:
uri:f61d0a49-009b-43d8-ac57-cf16d286f0e5
UUID:
uuid:f61d0a49-009b-43d8-ac57-cf16d286f0e5
Local pid:
pubs:691584

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