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Brefeldin A inhibits pestivirus release from infected cells, without affecting its assembly and infectivity.

Abstract:

The enveloped bovine viral diarrhea virus (BVDV) is a member of the Pestivirus genus within the Flaviviridae family. While considerable information has been gathered on virus entry into the host cell, genome structure and protein function, little is known about pestivirus morphogenesis and release from cells. Here, we analyzed the intracellular localization, N-glycan processing and secretion of BVDV using brefeldin A (BFA), which blocks protein export from the endoplasmic reticulum (ER) and c...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bbrc.2006.06.023

Authors


Macovei, A More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Branza-Nichita, N More by this author
Publisher:
Elsevier Publisher's website
Journal:
Biochemical and biophysical research communications Journal website
Volume:
346
Issue:
3
Pages:
1083-1090
Publication date:
2006
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:f6183ab5-afe5-4855-a8bb-3b20d79d8b50
Source identifiers:
99857
Local pid:
pubs:99857

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