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Neonatal diabetes and the KATP channel: From mutation to therapy.

Abstract:

Activating mutations in one of the two subunits of the ATP-sensitive potassium (KATP) channel cause neonatal diabetes (ND). This may be either transient or permanent and, in approximately 20% of patients, is associated with neurodevelopmental delay. In most patients, switching from insulin to oral sulfonylurea therapy improves glycemic control and ameliorates some of the neurological disabilities. Here, we review how KATP channel mutations lead to the varied clinical phenotype, how sulfonylur...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.tem.2017.02.003

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Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Department:
Corpus Christi College
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Publisher:
Elsevier Publisher's website
Journal:
Trends in Endocrinology & Metabolism Journal website
Volume:
28
Issue:
5
Pages:
377-387
Publication date:
2017-03-05
Acceptance date:
2017-03-03
DOI:
EISSN:
1879-3061
ISSN:
1043-2760
Pubs id:
pubs:685382
URN:
uri:f6126faf-c984-4b14-8c8e-d47d1f5d99fb
UUID:
uuid:f6126faf-c984-4b14-8c8e-d47d1f5d99fb
Local pid:
pubs:685382

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