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Neonatal diabetes and the KATP channel: From mutation to therapy.

Abstract:

Activating mutations in one of the two subunits of the ATP-sensitive potassium (KATP) channel cause neonatal diabetes (ND). This may be either transient or permanent and, in approximately 20% of patients, is associated with neurodevelopmental delay. In most patients, switching from insulin to oral sulfonylurea therapy improves glycemic control and ameliorates some of the neurological disabilities. Here, we review how KATP channel mutations lead to the varied clinical phenotype, how sulfonylur...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
Corpus Christi College
Role:
Author
More from this funder
Name:
European Research Council
Grant:
332620
More from this funder
Name:
Wellcome Trust
Grant:
089795
Publisher:
Elsevier
Journal:
Trends in Endocrinology & Metabolism More from this journal
Volume:
28
Issue:
5
Pages:
377-387
Publication date:
2017-03-01
Acceptance date:
2017-03-03
DOI:
EISSN:
1879-3061
ISSN:
1043-2760
Language:
English
Keywords:
Pubs id:
pubs:685382
UUID:
uuid:f6126faf-c984-4b14-8c8e-d47d1f5d99fb
Local pid:
pubs:685382
Source identifiers:
685382
Deposit date:
2017-07-18

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