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Brain microstructure reveals early abnormalities more than two years prior to clinical progression from mild cognitive impairment to Alzheimer's disease.

Abstract:

Diffusion imaging is a promising marker of microstructural damage in neurodegenerative disorders, but interpretation of its relationship with underlying neuropathology can be complex. Here, we examined both volumetric and brain microstructure abnormalities in 13 amnestic patients with mild cognitive impairment (MCI), who progressed to probable Alzheimer's disease (AD) no earlier than 2 years after baseline scanning, in order to focus on early, and hence more sensitive, imaging markers. We com...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Monsch, AU More by this author
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Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
33
Issue:
5
Pages:
2147-2155
Publication date:
2013-01-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:f60cf412-a666-4b54-b6ad-f78a7f8e953c
Source identifiers:
375703
Local pid:
pubs:375703

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