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Journal article

Micropatterning of costimulatory ligands enhances CD4+ T cell function.

Abstract:

Spatial organization of signaling complexes is a defining characteristic of the immunological synapse (IS), but its impact on cell communication is unclear. In T cell-APC pairs, more IL-2 is produced when CD28 clusters are segregated from central supramolecular activation cluster (cSMAC)-localized CD3 and into the IS periphery. However, it is not clear in these cellular experiments whether the increased IL-2 is driven by the pattern itself or by upstream events that precipitate the patterns. ...

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Publisher copy:
10.1073/pnas.0710295105

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
105
Issue:
22
Pages:
7791-7796
Publication date:
2008-06-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:f5fe7c55-e0c2-45e9-b080-c106a91fea61
Source identifiers:
426316
Local pid:
pubs:426316

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