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Designing novel modulators selective for the intermediate conductance calcium activated potassium channel

Abstract:

Reduction of systemic vascular resistance by dilation of resistance arteries, is a powerful method of blood pressure reduction. Endothelium derived hyperpolarisation is a major vasorelaxant pathway in resistance arteries, dependant on the activation of endothelium Ca2+ activated K+ (KCa) channels. Existing positive modulators of KCa channels act by stabilising the protein-protein interaction of the KCa channel gating complex, involving...

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MSD
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Author

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Name:
British Heart Foundation Centre of Research Excellence
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:f5f720fe-2e38-4299-bfc3-4b6eb3d37b57
Deposit date:
2019-10-29

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