Journal article

Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety

Abstract:: A series of 3-methylidene-1H-indol-2(3H)-ones substituted with a 5- or 6-pentafluorosulfanyl group has been synthesized by a Knoevenagel condensation reaction of SF5-substituted oxindoles with a range of aldehydes. The resulting products were characterized by X-ray crystallography studies and were tested for biological activity versus a panel of cell lines and protein kinases. Some exhibited single digit nM activity.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Sansook, S., Ocasio, C. A., Day, I. J., Tizzard, G. J., Coles, S. J., Fedorov, O., Bennett, J. M., Elkins, J. M., & Spencer, J. (2017). Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety. Organic & Biomolecular Chemistry, 15(40), 8655–8660.

MLA Style

Sansook, S., et al. “Synthesis of Kinase Inhibitors Containing a Pentafluorosulfanyl Moiety.” Organic & Biomolecular Chemistry, vol. 15, no. 40, Royal Society of Chemistry, 2017, pp. 8655–60.

Chicago Style

Sansook, S, CA Ocasio, IJ Day, GJ Tizzard, SJ Coles, O Fedorov, JM Bennett, JM Elkins, and J Spencer. 2017. “Synthesis of Kinase Inhibitors Containing a Pentafluorosulfanyl Moiety.” Organic & Biomolecular Chemistry 15 (40): 8655–60.
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Files:: c7ob02289a.pdf

(Preview, Version of record, pdf, 976.1KB, Terms of use)

Publisher copy:: 10.1039/c7ob02289a

Authors

+ Sansook, S More by this author

Role:: Author

+ Ocasio, CA More by this author

Role:: Author

+ Day, IJ More by this author

Role:: Author

+ Tizzard, GJ More by this author

Role:: Author

+ Coles, SJ More by this author

Role:: Author

More authors...

+ European Research Council More from this funder

Funding agency for:: Ocasio, CA
Grant:: PIIF-GA-2011-301062

+ Wellcome Trust More from this funder

Grant:: 092809/Z/10/Z

+ Royal Thai Government More from this funder

Funding agency for:: Sansook, S

Publisher:: Royal Society of Chemistry
Journal:: Organic & Biomolecular Chemistry More from this journal
Volume:: 15
Issue:: 40
Pages:: 8655-8660
Publication date:: 2017-09-29
Acceptance date:: 2017-09-28
DOI:: 10.1039/c7ob02289a
EISSN:: 1477-0539
ISSN:: 1477-0520
Pmid:: 28984325

Language:: English
Keywords:: Journal Article
Pubs id:: pubs:737200
UUID:: uuid:f5dac73d-3082-4f67-a166-1a69d1f48072
Local pid:: pubs:737200
Deposit date:: 2017-10-20

Terms of use

Copyright date:: 2017
Notes:: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence

Licence:: CC Attribution (CC BY)

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