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Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety

Abstract:
A series of 3-methylidene-1H-indol-2(3H)-ones substituted with a 5- or 6-pentafluorosulfanyl group has been synthesized by a Knoevenagel condensation reaction of SF5-substituted oxindoles with a range of aldehydes. The resulting products were characterized by X-ray crystallography studies and were tested for biological activity versus a panel of cell lines and protein kinases. Some exhibited single digit nM activity.
Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1039/c7ob02289a

Authors


More from this funder
Name:
European Research Council
Funding agency for:
Ocasio, CA
Grant:
PIIF-GA-2011-301062
More from this funder
Name:
Wellcome Trust
Grant:
092809/Z/10/Z
More from this funder
Name:
Royal Thai Government
Funding agency for:
Sansook, S
Publisher:
Royal Society of Chemistry
Journal:
Organic & Biomolecular Chemistry More from this journal
Volume:
15
Issue:
40
Pages:
8655-8660
Publication date:
2017-09-29
Acceptance date:
2017-09-28
DOI:
EISSN:
1477-0539
ISSN:
1477-0520
Pmid:
28984325
Language:
English
Keywords:
Pubs id:
pubs:737200
UUID:
uuid:f5dac73d-3082-4f67-a166-1a69d1f48072
Local pid:
pubs:737200
Deposit date:
2017-10-20

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