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Mathematical modelling of cell layer growth in a hollow fibre bioreactor

Abstract:

Generating autologous tissue grafts of a clinically useful volume requires efficient and controlled expansion of cell populations harvested from patients. Hollow fibre bioreactors show promise as cell expansion devices, owing to their potential for scale-up. However, further research is required to establish how to specify appropriate hollow fibre bioreactor operating conditions for expanding different cell types. In this study we develop a simple model for the growth of a cell layer seeded o...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.jtbi.2017.01.016

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Department:
Oxford, MPLS, Computer Science
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Department:
Linacre College
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Department:
Keble College
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Department:
Oxford, MPLS, Mathematical Institute
Shipley, RJ More by this author
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Grant:
Studentship through the Life Sciences Interface Doctoral Training Centre
Publisher:
Elsevier Publisher's website
Journal:
Journal of Theoretical Biology Journal website
Volume:
418
Pages:
36–56
Publication date:
2017-01-12
Acceptance date:
2017-01-09
DOI:
EISSN:
1095-8541
ISSN:
0022-5193
Pubs id:
pubs:668851
URN:
uri:f5c8dd0d-a2a5-4bc3-bafe-35bdbdc73c3c
UUID:
uuid:f5c8dd0d-a2a5-4bc3-bafe-35bdbdc73c3c
Local pid:
pubs:668851

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