Journal article icon

Journal article

External beam radiation therapy and enadenotucirev: Inhibition of the DDR and mechanisms of radiation-mediated virus increase

Abstract:

Ionising radiation causes cell death through the induction of DNA damage, particularly double-stranded DNA (dsDNA) breaks. Evidence suggests that adenoviruses inhibit proteins involved in the DNA damage response (DDR) to prevent recognition of double-stranded viral DNA genomes as cellular dsDNA breaks. We hypothesise that combining adenovirus treatment with radiotherapy has the potential for enhancing tumour-specific cytotoxicity through inhibition of the DDR and augmentation of virus product...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.3390/cancers12040798

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
ORCID:
0000-0002-4436-360X
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
ORCID:
0000-0001-5196-0552
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Publisher:
MDPI
Journal:
Cancers More from this journal
Volume:
12
Issue:
4
Article number:
798
Publication date:
2020-03-26
Acceptance date:
2020-03-24
DOI:
EISSN:
2072-6694
ISSN:
2072-6694
Language:
English
Keywords:
Pubs id:
1096686
Local pid:
pubs:1096686
Deposit date:
2020-03-26

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP