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Efficiency of excision of 8-oxo-guanine within DNA clustered damage by XRS5 nuclear extracts and purified human OGG1 protein.

Abstract:

A major DNA lesion is the strongly mutagenic 8-oxo-7,8-dihydroguanine (8-oxoG) base, formed by oxidative attack at guanine and which leads to a high level of G.C-->T.A transversions. Clustered DNA damages are formed in DNA following exposure to ionizing radiation or radiomimetic anticancer agents and are thought to be biologically severe. The presence of 8-oxoG within clustered DNA damage may present a challenge to the repair machinery of the cell, if the OGG1 DNA glycosylase/AP lyase prot...

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Publication status:
Published

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Publisher copy:
10.1021/bi0112356

Authors


David-Cordonnier, MH More by this author
Boiteux, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Journal:
Biochemistry
Volume:
40
Issue:
39
Pages:
11811-11818
Publication date:
2001-10-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:f5bab949-25d7-4a93-860b-3a5fb2b010cd
Source identifiers:
131004
Local pid:
pubs:131004

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