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An oxidatively-activated safety catch linker for solid phase synthesis.

Abstract:

A N-benzyl-4-amino-2,2-dimethylbutanoic acid-based system has been developed as a new oxidatively activated safety catch linker for reaction monitoring and optimisation on solid support. The CAN promoted oxidative debenzylation of the tertiary N-benzylamine moiety, followed by concomitant cyclisation and release of alcohols and amines has been demonstrated both in solution phase model studies and on the solid phase. The linker system has been applied to the solid phase synthesis of a collecti...

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Publication status:
Published

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Publisher copy:
10.1039/b802204f

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Organic and biomolecular chemistry More from this journal
Volume:
6
Issue:
9
Pages:
1625-1634
Publication date:
2008-05-01
DOI:
EISSN:
1477-0539
ISSN:
1477-0520
Language:
English
Keywords:
Pubs id:
pubs:34205
UUID:
uuid:f581d781-c437-4149-9715-44b245015332
Local pid:
pubs:34205
Source identifiers:
34205
Deposit date:
2012-12-19

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