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Genetic control of plasma lipid levels in a cross derived from normoglycaemic Brown Norway and spontaneously diabetic Goto-Kakizaki rats.

Abstract:

AIMS/HYPOTHESIS: Dyslipidaemia is a main component of the insulin resistance syndrome. The inbred Goto-Kakizaki (GK) rat is a model of spontaneous type 2 diabetes and insulin resistance, which has been used to identify diabetes-related susceptibility loci in genetic crosses. The objective of our study was to test the genetic control of lipid metabolism in the GK rat and investigate a possible relationship with known genetic loci regulating glucose homeostasis in this strain. MATERIALS AND MET...

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Publication status:
Published

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Publisher copy:
10.1007/s00125-006-0396-z

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Journal:
Diabetologia
Volume:
49
Issue:
11
Pages:
2679-2688
Publication date:
2006-11-05
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
URN:
uuid:f561a35c-2047-42d9-ab1f-bb2b6ce611ae
Source identifiers:
20371
Local pid:
pubs:20371

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