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Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment

Abstract:

The mechanisms by which the major Polycomb group (PcG) complexes PRC1 and PRC2 are recruited to target sites in vertebrate cells are not well understood. Building on recent studies that determined a reciprocal relationship between DNA methylation and Polycomb activity, we demonstrate that, in methylation-deficient embryonic stem cells (ESCs), CpG density combined with antagonistic effects of H3K9me3 and H3K36me3 redirects PcG complexes to pericentric heterochromatin and gene-rich domains. Sur...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2014.04.012

Authors


Dienstbier, M More by this author
More by this author
Department:
Oxford, MSD, Biochemistry
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Wellcome Trust More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
Medical Research Council More from this funder
Publisher:
Elsevier Inc. Publisher's website
Journal:
Cell Reports Journal website
Volume:
7
Issue:
5
Pages:
1456-1470
Publication date:
2014-03-24
Acceptance date:
2014-12-17
DOI:
ISSN:
2211-1247
Pubs id:
pubs:471763
URN:
uri:f559f88d-5419-4982-af03-be9943fb8292
UUID:
uuid:f559f88d-5419-4982-af03-be9943fb8292
Local pid:
pubs:471763
Paper number:
5

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