Journal article
Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment
- Abstract:
-
The mechanisms by which the major Polycomb group (PcG) complexes PRC1 and PRC2 are recruited to target sites in vertebrate cells are not well understood. Building on recent studies that determined a reciprocal relationship between DNA methylation and Polycomb activity, we demonstrate that, in methylation-deficient embryonic stem cells (ESCs), CpG density combined with antagonistic effects of H3K9me3 and H3K36me3 redirects PcG complexes to pericentric heterochromatin and gene-rich domains. Sur...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
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(pdf, 4.0MB)
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- Publisher copy:
- 10.1016/j.celrep.2014.04.012
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Authors
Funding
Wellcome Trust
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Biotechnology and Biological Sciences Research Council
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Medical Research Council
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Bibliographic Details
- Publisher:
- Elsevier Inc. Publisher's website
- Journal:
- Cell Reports Journal website
- Volume:
- 7
- Issue:
- 5
- Pages:
- 1456-1470
- Publication date:
- 2014-03-24
- Acceptance date:
- 2014-12-17
- DOI:
- ISSN:
-
2211-1247
- Pubs id:
-
pubs:471763
- URN:
-
uri:f559f88d-5419-4982-af03-be9943fb8292
- UUID:
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uuid:f559f88d-5419-4982-af03-be9943fb8292
- Local pid:
- pubs:471763
- Paper number:
- 5
Item Description
Terms of use
- Copyright holder:
- Sarah Cooper et al.
- Copyright date:
- 2014
- Notes:
- This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/)
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