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Severe acute malnutrition results in lower lumefantrine exposure in children treated with artemether‐lumefantrine for uncomplicated malaria

Abstract:

Severe acute malnutrition (SAM) has been reported to be associated with increased malaria morbidity in Sub‐Saharan African children and may affect the pharmacology of antimalarial drugs. This population pharmacokinetic (PK)‐pharmacodynamic study included 131 SAM and 266 non‐SAM children administered artemether‐lumefantrine twice daily for 3 days. Lumefantrine capillary plasma concentrations were adequately described by two transit‐absorption compartments followed by two distribution compartme...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1002/cpt.1531

Authors


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Role:
Author
ORCID:
0000-0002-6575-6971
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Name:
Bill & Melinda Gates Foundation
Grant:
OPP1181807
Publisher:
American Society for Clinical Pharmacology and Therapeutics
Journal:
Clinical Pharmacology and Therapeutics More from this journal
Issue:
106
Article number:
6
Pages:
1299-1309
Publication date:
2019-07-23
Acceptance date:
2019-05-08
DOI:
EISSN:
1532-6535
ISSN:
0009-9236
Pmid:
31152555
Language:
English
Keywords:
Pubs id:
pubs:1012622
UUID:
uuid:f545d7ad-a3e0-46fa-836c-85ad47d46cd3
Local pid:
pubs:1012622
Source identifiers:
1012622
Deposit date:
2019-08-04

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