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Plasma metabolomics implicates modified transfer RNAs and altered bioenergetics in the outcomes of pulmonary arterial hypertension

Abstract:
Background: Pulmonary arterial hypertension (PAH) is a heterogeneous disorder with high mortality. Methods: We conducted a comprehensive study of plasma metabolites using ultraperformance liquid chromatography mass spectrometry to identify patients at high risk of early death, to identify patients who respond well to treatment, and to provide novel molecular insights into disease pathogenesis. Results: Fifty-three circulating metabolites di... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1161/circulationaha.116.024602

Authors


Rhodes, CJ More by this author
Ghataorhe, P More by this author
Wharton, J More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
KIR
ORCID:
0000-0003-3899-3872
More by this author
ORCID:
0000-0002-7794-3432
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Publisher:
American Heart Association Publisher's website
Journal:
Circulation Journal website
Volume:
135
Issue:
5
Pages:
460-475
Publication date:
2016-11-21
Acceptance date:
2016-11-09
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
Pubs id:
pubs:665958
URN:
uri:f5373f16-e649-40f0-aa61-dee4db9edd4f
UUID:
uuid:f5373f16-e649-40f0-aa61-dee4db9edd4f
Local pid:
pubs:665958

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