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Modelling genotypes in their microenvironment to predict single- and multi-cellular behaviour

Abstract:

A cell's phenotype is the set of observable characteristics resulting from the interaction of the genotype with the surrounding environment, determining cell behaviour. Deciphering genotype-phenotype relationships has been crucial to understand normal and disease biology. Analysis of molecular pathways has provided an invaluable tool to such understanding; however, it does typically not consider the physical microenvironment, which is a key determinant of phenotype. In this study, we present...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/gigascience/giz010

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
IT Services
Role:
Author
More by this author
Institution:
University of Oxford
Division:
IT Services
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
ORCID:
0000-0003-0409-406X
More from this funder
Name:
Cancer Research
Grant:
23969
Publisher:
Oxford University Press
Journal:
GigaScience More from this journal
Volume:
8
Issue:
3
Pages:
giz010
Publication date:
2019-01-31
Acceptance date:
2019-01-15
DOI:
EISSN:
2047-217X
Keywords:
Pubs id:
pubs:963553
UUID:
uuid:f51dbbb1-aa7e-448d-988e-d42822b365c0
Local pid:
pubs:963553
Source identifiers:
963553
Deposit date:
2019-01-17

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