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Journal article

OTULIN deficiency causes auto-inflammatory syndrome

Abstract:
Ubiquitin chains assembled via the N-terminal methionine (Met1; or linear ubiquitin), conjugated by the linear ubiquitin chain assembly complex (LUBAC), participate in NF- dependent inflammatory signaling and immune responses. A recent report in Cell finds that OTULIN, a deubiquitinase that selectively cleaves Met1-linked ubiquitin chains, is essential for restraining inflammation in vivo.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/cr.2016.113

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Department:
Oxford, MSD, NDM, Oxford Ludwig Institute
More by this author
Department:
Oxford, MSD, NDM, Oxford Ludwig Institute
Publisher:
Nature Publishing Group Publisher's website
Journal:
Cell Research Journal website
Volume:
26
Pages:
1176-1177
Publication date:
2016-08-05
Acceptance date:
2016-08-31
DOI:
ISSN:
1748-7838
Pubs id:
pubs:645751
URN:
uri:f4f326df-9948-46b1-901d-f3ef7badf231
UUID:
uuid:f4f326df-9948-46b1-901d-f3ef7badf231
Local pid:
pubs:645751

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