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Maternal immune activation downregulates schizophrenia genes in the foetal mouse brain

Abstract:

Susceptibility to schizophrenia is mediated by genetic and environmental risk factors. Maternal immune activation by infections during pregnancy is hypothesized to be a key environmental risk factor. However, little is known about how maternal immune activation contributes to schizophrenia pathogenesis. In this study, we investigated if maternal immune activation influences the expression of genes associated with schizophrenia in foetal mouse brains. We found that two sets of schizophrenia ge...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/braincomms/fcab275

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
ORCID:
0000-0002-8242-3722
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
ORCID:
0000-0002-0377-5536
Publisher:
Oxford University Press
Journal:
Brain Communications More from this journal
Volume:
3
Issue:
4
Article number:
fcab275
Publication date:
2021-11-15
Acceptance date:
2021-10-12
DOI:
EISSN:
2632-1297
ISSN:
2632-1297
Pmid:
34859219
Language:
English
Keywords:
Pubs id:
1218976
Local pid:
pubs:1218976
Deposit date:
2022-03-24

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