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Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease

Abstract:

Alzheimer's disease (AD) is a neurodegenerative pathology with relevant unmet therapeutic needs. Both natural aging and AD have been associated with a significant decline in the omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA), and accordingly, administration of DHA has been proposed as a possible treatment for this pathology. However, recent clinical trials in mild-to-moderately affected patients have been inconclusive regarding the real efficacy of DHA in halting this disease. ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


Fiol-Deroque, MA More by this author
Marcilla-Etxenike, A More by this author
Ahyayauch, H More by this author
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Ministerio de Economía y Competitividad More from this funder
Govern de les Illes Balears More from this funder
Marathon Foundation More from this funder
Imperial College London More from this funder
Publisher:
Elsevier B.V. Publisher's website
Journal:
Biochimica et Biophysica Acta Journal website
Volume:
1838
Issue:
6
Pages:
1680–1692
Publication date:
2014-06-05
DOI:
ISSN:
0006-3002 and 1879-2642
Pubs id:
pubs:614441
URN:
uri:f4d5b72c-da6f-4ebf-8dd0-7796f93343ea
UUID:
uuid:f4d5b72c-da6f-4ebf-8dd0-7796f93343ea
Local pid:
pubs:614441

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