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The impact of different strategies to handle missing data on both precision and bias in a drug safety study: a multidatabase multinational population-based cohort study

Abstract:
Background: Missing data are often an issue in electronic medical records (EMRs) research. However, there are many ways that people deal with missing data in drug safety studies. Aim: To compare the risk estimates resulting from different strategies for the handling of missing data in the study of venous thromboembolism (VTE) risk associated with antiosteoporotic medications (AOM). Methods: New users of AOM (alendronic acid, other bisphosphon... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.2147/CLEP.S154914

Authors


Martin-Merino, E More by this author
Calderón-Larrañaga, A More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; CSM
Poblador-Plou, B More by this author
Llorente, A More by this author
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National Osteoporosis Society More from this funder
Publisher:
Dove Press Publisher's website
Journal:
Clinical Epidemiology Journal website
Volume:
2018/10
Pages:
643—654
Publication date:
2018-06-05
Acceptance date:
2018-02-11
DOI:
ISSN:
1179-1349
Pubs id:
pubs:824235
URN:
uri:f4b3ab28-b362-4dcf-96ef-072b860dedb5
UUID:
uuid:f4b3ab28-b362-4dcf-96ef-072b860dedb5
Local pid:
pubs:824235

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