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Investigation of slow-wave activity saturation during surgical anesthesia reveals a signature of neural inertia in humans

Abstract:
Background: Previously, we showed experimentally that saturation of slow-wave activity provides a potentially individualized neurophysiologic endpoint for perception loss during anesthesia. Furthermore, it is clear that induction and emergence from anesthesia are not symmetrically reversible processes. The observed hysteresis is potentially underpinned by a neural inertia mechanism as proposed in animal studies. Methods: In an advanced secondary analysis of 3... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1097/aln.0000000000001759

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
Sleigh, JW More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
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Grant:
Confidence in Concept (BRR00010-HM01)
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Grant:
LUMINOUS project H2020-FETOPEN-2014-2015-35 RIA under agreement No. 686764
Publisher:
Lippincott, Williams & Wilkins Publisher's website
Journal:
Anesthesiology Journal website
Volume:
127
Issue:
4
Pages:
645-657
Publication date:
2017-10-01
Acceptance date:
2017-05-04
DOI:
EISSN:
1528-1175
ISSN:
0003-3022
Pubs id:
pubs:707998
URN:
uri:f4adc142-364b-44d6-acd0-694ee4a78ab4
UUID:
uuid:f4adc142-364b-44d6-acd0-694ee4a78ab4
Local pid:
pubs:707998
Language:
English

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