Journal article icon

Journal article

Key role of the GITR/GITRLigand pathway in the development of murine autoimmune diabetes: a potential therapeutic target.

Abstract:

BACKGROUND: The cross-talk between pathogenic T lymphocytes and regulatory T cells (Tregs) plays a major role in the progression of autoimmune diseases. Our objective is to identify molecules and/or pathways involved in this interaction and representing potential targets for innovative therapies. Glucocorticoid-induced tumor necrosis factor receptor (GITR) and its ligand are key players in the T effector/Treg interaction. GITR is expressed at low levels on resting T cells and is significantly...

Expand abstract
Publication status:
Published

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pone.0007848

Authors


Journal:
PloS one More from this journal
Volume:
4
Issue:
11
Pages:
e7848
Publication date:
2009-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP