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An allele-specific gene expression assay to test the functional basis of genetic associations.

Abstract:

The number of significant genetic associations with common complex traits is constantly increasing. However, most of these associations have not been understood at molecular level. One of the mechanisms mediating the effect of DNA variants on phenotypes is gene expression, which has been shown to be particularly relevant for complex traits. This method tests in a cellular context the effect of specific DNA sequences on gene expression. The principle is to measure the relative abundance of tra...

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Publisher copy:
10.3791/2279

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Knight, JC More by this author
Journal:
Journal of visualized experiments : JoVE
Issue:
45
Pages:
104
Publication date:
2010
DOI:
EISSN:
1940-087X
ISSN:
1940-087X
URN:
uuid:f49effc3-267e-441b-bcd5-418925f3e523
Source identifiers:
95900
Local pid:
pubs:95900

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