Mechanisms at the cellular level during induction of high zone tolerance in vitro.
The in vitro induction of high zone tolerance to polymerized flagellin of S. adelaide in CBA mouse spleen cells consists of two stages: (a) Attachment of tolerance inducing concentrations of antigen to the surface of immunocompetent cells. (b) Inactivation of the immunocompetent cells by the surface-bound antigen. The definition of these two stages is based on the finding that trypsin treatment of spleen cells within 16 hr after tolerance induction in vitro completely reverses the state of un...Expand abstract
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