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Circulating insulin‐like growth factor‐I, total and free testosterone concentrations and prostate cancer risk in 200 000 men in UK Biobank

Abstract:

Insulin‐like growth factor‐I (IGF‐I) and testosterone have been implicated in prostate cancer aetiology. Using data from a large prospective full‐cohort with standardised assays and repeat blood measurements, and genetic data from an international consortium, we investigated the associations of circulating IGF‐I, sex hormone‐binding globulin (SHBG), and total and calculated free testosterone concentrations with prostate cancer incidence and mortality. For prospective analyses, risk was estima...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/ijc.33416

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Oxford college:
Wolfson College
Role:
Author
ORCID:
0000-0001-9229-2589
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Cancer Epidemiology Unit
Role:
Author
ORCID:
0000-0003-0979-4436
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Cancer Epidemiology Unit
Role:
Author
ORCID:
0000-0002-5652-356X
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
Publisher:
Wiley
Journal:
International Journal of Cancer More from this journal
Volume:
148
Issue:
9
Pages:
2274-2288
Publication date:
2020-12-11
Acceptance date:
2020-11-16
DOI:
EISSN:
1097-0215
ISSN:
0020-7136
Language:
English
Keywords:
Pubs id:
1099234
Local pid:
pubs:1099234
Deposit date:
2020-11-19

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