Analysis of the murine 5-HT receptor gene promoter in vitro and in vivo.

Journal article

The expression level of the 5-HT(1A) receptor gene (htr1a) in the central nervous system (CNS) is implicated in the aetiology and treatment of anxiety disorders and depression. Previous studies of the murine htr1a have revealed that its proximal promoter is GC rich and TATA-less. Several functional transcription factor binding sites, including MAZ and SP1 recognition sequences, have been identified. To further analyse the promoter of this receptor gene, additional upstream sequence informatio...

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Authors: Ansorge, M; Tanneberger, C; Davies, B; Theuring, F; Kusserow, H

• Journal: European journal of neuroscience
• Volume: 20
• Issue: 2
• Pages: 363-374
• Publication date: 2004-07-01
• DOI: 10.1111/j.1460-9568.2004.03472.x
• EISSN: 1460-9568
• ISSN: 0953-816X
• Language: English
• Keywords: Mice, Transgenic; Animals; Regulatory Sequences, Nucleic Acid; beta-Galactosidase; Mice; Genes, Reporter; Central Nervous System; Neuroblastoma; Promoter Regions, Genetic; Cell Count; In Situ Hybridization; Receptor, Serotonin, 5-HT1A; Cell Line; Gene Expression Regulation; Transgenes