MRI imaging for sensitive tumour cell-tracking during development of early brain metastasis in a preclinical model

Conference item

Breast cancer patients frequently develop brain metastases. Conventional treatment is palliative and often involves whole-brain radiotherapy. There is a pressing unmet therapeutic need to treat brainmetastasis at an early stage, when relatively few tumor cells have invaded the brain parenchyma. However, to evaluate the efficacy of new therapeutic treatments, preclinical models of early stage brain metastases and tools to monitor response to treatment are needed. The aim of this study was to develop a model in which early brain metastases can be tracked by MRI using microparticles of iron oxide (MPIO).

Authors: Corroyer-Dulmont, A; Valable, S; Falzone, N; Sibson, NR; Bernaudin, M

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: SAGE Publications
• Host title: Journal of Cerebral Blood Flow and Metabolism
• Journal: 28rd International Symposium on Cerebral Blood Flow, Metabolism and Function and the 13th International Conference on Quantification of Brain Function (BRAIN and BRAIN PET 2017)
• Volume: 37
• Pages: 323-324
• Publication date: 2017-04-01
• Acceptance date: 2017-01-13
• DOI: 10.1177/0271678X17695991
• EISSN: 1559-7016
• ISSN: 0271-678X