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Molecular modeling correctly predicts the functional importance of Phe594 in transmembrane helix 11 of the multidrug resistance protein, MRP1 (ABCC1).

Abstract:

The human ATP-binding cassette (ABC) transporter, multidrug resistance protein 1 (MRP1/ABCC1), confers resistance to a broad range of anti-cancer agents and transports a variety of organic anions. At present, essentially no structural data exists for MRP1 that might be used to elucidate its mechanism of transport. Consequently, we have applied a modeling strategy incorporating crystal and indirect structural data from other ABC transporters to construct a model of the transmembrane domains of...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m310711200

Authors


Campbell, JD More by this author
Sansom, MS More by this author
Deeley, RG More by this author
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Journal:
The Journal of biological chemistry
Volume:
279
Issue:
1
Pages:
463-468
Publication date:
2004-01-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:f3ae4d9b-711c-41d9-841f-425cae39a514
Source identifiers:
100687
Local pid:
pubs:100687

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