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Modelling incremental benefits on complications rates when targeting lower HbA1c levels in people with Type 2 diabetes and cardiovascular disease

Abstract:

Glucose-lowering interventions in Type 2 diabetes mellitus have demonstrated reductions in microvascular complications and modest reductions in macrovascular complications. However, the degree to which targeting different HbA1c reductions might reduce risk is unclear.Participant-level data for Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS) participants with established cardiovascular disease were used in a Type 2 diabetes-specific simulation model to quantify the likely imp...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1111/dme.13533

Authors


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Role:
Author
ORCID:
0000-0002-0415-7908
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
OCDEM
Role:
Author
ORCID:
0000-0002-5194-8550
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Population Health
Role:
Author
ORCID:
0000-0003-0239-7278
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
OCDEM
Role:
Author
ORCID:
0000-0002-1256-874X
More from this funder
Name:
Academy of Medical Sciences
Grant:
SGL015\1017
More from this funder
Name:
Medical Research Council
Grant:
G0801042
Publisher:
Wiley
Journal:
Diabetic Medicine More from this journal
Volume:
35
Issue:
1
Pages:
72-77
Publication date:
2017-11-16
Acceptance date:
2017-10-17
DOI:
EISSN:
1464-5491
ISSN:
0742-3071
Pmid:
29057545
Language:
English
Keywords:
Pubs id:
pubs:738531
UUID:
uuid:f3930b1d-7c97-4e04-b098-05060d1759ce
Local pid:
pubs:738531
Source identifiers:
738531
Deposit date:
2019-03-06

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