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BRAF/MAPK and GSK3 signalling converge to control MITF nuclear export

Abstract:

The close integration of the MAPK, PI3K, and WNT signaling pathways underpins much of development and is deregulated in cancer. In principle, combinatorial posttranslational modification of key lineage-specific transcription factors would be an effective means to integrate critical signaling events. Understanding how this might be achieved is central to deciphering the impact of microenvironmental cues in development and disease. The microphthalmia-associated transcription factor MITF plays a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1810498115

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Oxford Ludwig Institute
Role:
Author
More from this funder
Name:
Wellcome Trust Career Development Fellowship
Funding agency for:
Picaud, S
Filippakopoulos, P
Grant:
095751/Z/11/Z
095751/Z/11/Z
More from this funder
Name:
The Rosetrees Trust
Funding agency for:
Ngeow, KC
Grant:
M456
More from this funder
Name:
Arthritis Research UK
Funding agency for:
Ngeow, KC
Grant:
M456
More from this funder
Name:
Cancer Research UK
Funding agency for:
Ngeow, KC
Grant:
M456
More from this funder
Name:
A*STAR Singapore
Funding agency for:
Ngeow, KC
Grant:
M456
Publisher:
National Academy of Sciences
Journal:
Proceedings of the National Academy of Sciences More from this journal
Volume:
115
Issue:
37
Pages:
E8668-E8677
Publication date:
2018-09-11
Acceptance date:
2018-08-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Keywords:
Pubs id:
pubs:894283
UUID:
uuid:f360ab9f-b925-43af-afc8-c1d56c9f3b18
Local pid:
pubs:894283
Source identifiers:
894283
Deposit date:
2018-08-06

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