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Decoding movement states in stepping cycles based on subthalamic LFPs in Parkinsonian patients

Abstract:

Gait disturbances are a prominent feature of Parkinson's disease (PD), often refractory to medication or continuous deep brain stimulation (DBS) on basal ganglia targets such as the subthalamic nucleus (STN). Here we sought to identify movement states during stepping cycles, such as left leg stance and right leg stance. To this end we analyzed local field potential (LFP) activity in STN using a combination of the multivariate autoregressive (MAR) model and the Hidden Markov model (HMM). Our r...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1109/EMBC.2018.8512545

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
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Name:
Medical Research Council
Grant:
MR/P012272/1
More from this funder
Name:
National Institute for Health Research Oxford Biomedical Research Centre
Publisher:
Institute of Electrical and Electronics Engineers
Journal:
40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) More from this journal
Volume:
2018
Pages:
1384-1387
Publication date:
2018-10-29
Acceptance date:
2018-05-06
DOI:
EISSN:
1557-170X
Pmid:
30440650
Language:
English
Keywords:
Pubs id:
pubs:948952
UUID:
uuid:f33e7da5-dc59-4bdc-b4f6-6f20d63f29ee
Local pid:
pubs:948952
Source identifiers:
948952
Deposit date:
2019-02-18

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