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A single amino acid residue regulates PTEN-binding and stability of the spinal muscular atrophy protein SMN

Abstract:

Spinal Muscular Atrophy (SMA) is a neuromuscular disease caused by decreased levels of the survival of motoneuron (SMN) protein. Post-translational mechanisms for regulation of its stability are still elusive. Thus, we aimed to identify regulatory phosphorylation sites that modulate function and stability. Our results show that SMN residues S290 and S292 are phosphorylated, of which SMN pS290 has a detrimental effect on protein stability and nuclear localization. Furthermore, we propose that ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0002-1592-9838
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Role:
Author
ORCID:
0000-0002-6421-5778
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Role:
Author
ORCID:
0000-0002-4094-9996
Publisher:
MDPI
Journal:
Cells More from this journal
Volume:
9
Issue:
11
Article number:
2405
Publication date:
2020-11-03
Acceptance date:
2020-10-27
DOI:
EISSN:
2073-4409
Pmid:
33153033
Language:
English
Keywords:
Pubs id:
1147093
Local pid:
pubs:1147093
Deposit date:
2021-02-25

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